绞股兰在原发性肺癌放疗和化疗中对细胞免疫功能的保护作用

PROTECTIVE EFFECT OF JIAOGULAN ON CELLULAR IMMUNITY OF THE PATIENTS WITH PRIMARY LUNG CANCER TREATED BY RADIOTHERAPY PLUS CHEMOTHERAPY

在接受联合放疗和化疗的原发性肺癌患者，前瞻性地观察绞股兰对细胞免疫功能和预后的作用。结果：对照组联合放疗和化疗后患者的免疫功能受到明显的再抑制；绞股兰组口服绞股兰总甙片（每次６０～８０ｍｇ，每天３次，６０ｄ），免疫功能状态保持不变；一年后随访，绞股兰组和对照组的肿瘤远处转移率，远处转移出现的中位时间以及６个月，１２个月的肿瘤局部控制率和生存率，虽然在统计学上无明显差异，但前者有优于后者的趋势。结果表明，绞股兰在原发性肺癌患者接受联合放疗和化疗中对细胞免疫功能具有保护作用。

The aim of the clinical trial in the patients with lung cancer treated by combined radiotherapy and chemotherapy was to prospectively observe the effect of jiaogulan on the cellular immunity and prognosis.The results: cellular immunity of the control group was further suppressed;when the patients take jiaogulan tables(180～240mg/day) during the therapy period (60 days) the immune situation could keep no change. Comparing the jiaogulan group with the control group after a year,although there were no significant differences in statistics on the distant metastatic rate,the medial time of distant metastasis and the local tumor control rate and survival rate of 6 and 12 months respectively, but the trend that the prognosis of the former was superior to the latter could be found.The results show that jiaogulan can protect patient's cellular immunity when the patients receiving radiotherapy plus chemotherapy.