肝硬化及肝细胞癌组织中硫酸软骨素的免疫组化研究

AN IMMUNOHISTOCHEMICAL STUDY OF CHONDROITIN SULFATE IN CIRRHOTIC LIVER TISSUE AND HEPATOCELLULAR CARCINOMA

本文应用ＰＡＰ免疫组织化学法测定人正常肝脏、肝硬化及肝细胞癌组织中的硫酸软骨素（ＣｈｏｎｄｒｏｉｔｉｎＳｕｌｆａｔｅ，ＣＳ），发现正常肝脏中ＣＳ多散在分布于肝脏细胞中和肝板表面，肝硬化组织中假小叶的纤维间隔和细胞外间质中ＣＳ大量不均匀分布，肝细胞癌组织亦见ＣＳ分布范围扩大，在癌细胞周围结缔组织中大量存在。提示：肝纤维化或癌变时伴随ＣＳ的大量合成和胞外沉积，对前者是参与纤维组织过度增生的重要因素，对后者可能是一种癌胚现象，与癌细胞增殖、浸润和转移有关。

Chondroitin sulfate(CS)in human normal liver,cirrhotic liver and hepatocellu-lar carcinoma(HCC)was studied with PAP immunohistochemical method,CS wasprescnt in various liver cells ,on the surfaces of hepatic plates and in extracellularmatrix in normal liver,Much more CS was found in connective tissues of cirrho- tic liver and HCC. The latter one might be a carcinoembryonic phenomenon,whichcould stimulate growth,infiltration and metastas is of tumor.