外源性hCG在人体尿液中消除时间、半衰期与妊娠关系

THE RELATIONSHIP BETWEEN PREGNANCY AND HALF-LIFE AND CLEARANCE OF THEEXOGENOUS HUMAN CHORIONIC GONADOTROPIN

采用酶联免疫法（ＥＬＩＳＡ）测定了注射人绒毛膜促性腺激素（ｈＣＧ）妇女尿液中ｈＣＧ含量。观察分析了外源性ｈＣＧ在尿中半衰期、清除时间。结果显示：外源性ｈＣＧ在尿液中的消除时间和半衰期分别为９天及８９．７４ｈ。确定注射ｈＣＧ２４ｈ的值为ｈＣＧ０，于注射第９天尿液中ｈＣＧ低于１０％ｈＣＧ０值。若于注射ｈＣＧ第９天定量测定尿ｈＣＧ，其水平＞１０％ｈＣＧ０值，提示有妊娠可能。

The human chorionic gonadotropin (hCG) in urine in women after injection ofhCG were determined by enzyme-linked immunosorbent assay (ELISA).The half-lifeand cearance of the exogenous hCG in urine were observed and analysed.The resultsshowed that the clearance and the half-life of exogenous hCG were 9 days and 89.74hours,respectively,in urine.The value observcd 24 hours after hCG injection is defi-ned as hCG_0,The value was found less than 10% of the hCG_0 value in urine on day9.The experimental results shewed that the urine hCG level measured on day 9,if>10% of the initial value,is suggestive of pregnancy.