抗高血压治疗对大鼠慢性肾衰的影响

The effects of antihypertensive drugs oncbronic renal failure in rat with subtotalnephrectomy

本文研究抗高血压药物治疗对５／６肾门除慢性肾衰ＳＤ大鼠的作用。所有大鼠随机分为四组，即正常对照组（Ｓｈａｍ）、５／６肾门除组（５／６Ｎｘ）、５／６肾切除＋依那普利组及５／６肾切除＋利血平、肼苯达嗪及双氢克尿噻三联抗高血压治疗组。结果示两种方法将血压控制在正常水平的条件下，５／６Ｎｘ大鼠尿蛋白排泄量、肾功能进行性恶化、肾小球面积及肾小球硬化病变均有不同程度的改善。提示抗高血压治疗一血管紧张素转换酶抑制剂或三联，除了具有降低残余肾小球毛细血管内静水压作用外，还可能通过抑制残余肾单位的代偿性肥大，而减少肾小球硬化，达到延缓慢性肾功能不全的目的。

he effects of antihypertensive drugswere investigated in the 516 nephrectomizedSD rat (Nx) associated with systemic hy-pertension. All rats were divided into fourgroups. Group 1 was sham rats as normal control (n=7) ,group 2 was 516 Nx with nospecific therapy (n= 7) ,group 3 was 5/6 Nxwith Enalapril ( 516 Nx + E ) (n = 7 ) . andgroup 4 was 516 Nx with triple therapy (5/ 6 Nx + T ) (Reserpine + Hydrolazine + Hy-drochlorotyiade ) (n = 7 ). In group 4, thetriple therapy normalized systemic hypertension as well as Enalapril therapy ingroup 3. Protienuria, creatinine clerance,glomerular area and glomerulosclerosis wereimproved significantly in 516 Nx+E and 5/6 Nx+T as compared with that in 5/6 Nx.These results suggest that systemic hypertension also play a role in the progression ofchronic renal failure, and not only the hypertesion, hyperperfution and hyperfiltra-tion but also the hypertrophy were im-proved by antihypertensive both triple andEnalapril therapy in surviving nephrons ofrat with 5/6 Nx.