乙酰－L－肉毒碱的合成

Synthesis of-L- Acetylcarnitine

研究了用ｌ－肉毒碱和乙酰氯为原料，以对甲苯磺酸为催化剂，冰乙酸为溶剂合成乙酰－ｌ－肉毒碱的方法，得出最佳反应温度为７０℃，最佳物料配比为：ｌ－肉毒碱：乙酰氯：对甲苯磺股＝１：９：０．３（摩尔比），反应收率达７８．１％，改进了提纯乙酰－ｌ－肉毒碱的方法．

The synthesis of l-acetylcarnitine from l-carnitine and acetyl chloride using toluene-4-sulfonic acid as catalyst and glacial acetic acid as solvent have been studied.A purifiedmethod of the product was also proposed. The optimal conditions of the reaction were as follows:reaction temperature is 70℃,molar ratio of reactionts is 1 :9:0.3(l-carnitine:acetyl chloride:toluene-4-sulfonic acid).The l-acetylcarnitine was obtained in 78.1% yield based on l-carnitine.