白细胞介素－2对肾小球上皮细胞部分生物学功能的影响

Effect of interleukin-2 on the biologicalfunction of glomerular epithelial cell in vit-ro

白细胞介素－２（ＩＬ－２）是免疫系统中重要的调节因子。原发性肾病综合征时，可见ＩＬ－２的产生和血清水平发生改变。为了探讨ＩＬ－２在肾病综合征发生、发展中的意义，本文运用肾小球细胞体外培养和双同位素标记方法，分别观察了ＩＬ－２对肾小球上皮细胞（ＧＥＣ）掺入３５Ｓ和３Ｈ－亮氨酸、３Ｈ－ＴｄＲ的影响。结果显示，ＩＬ－２抑制ＧＥＣ的增殖，但明显促进ＧＥＣ合成含硫化合物和蛋白质。

nterleukin-2 (IL-2) is an importantregulating factor in immune system. To ex-plore the effect of IL-2 on the proliferationof glomerular resident cells and their syn-thesis function in vitro,glomerular cell cul-ture and dual isotope labelling techniquewere used in this study. We investigated theinfluence of IL-2 on 3H-TdR uptake byglomerular epithelial cell (GEC) , and 35 Son 3H-Leucine incorporation in GEC. The re-sult showed that IL-2 inhibited the prolifer-ation of GEC ,and increased the synthesis ofsulfated compounds and protein by GEC.