金属硫蛋白与医学

Metallothionein and Medicine

立属硫蛋白是一类富含巯基与金属的内源性蛋白，化学结构极为特殊。该蛋白的特点为具有很强的诱导性，金属、糖皮质激素、某些化合物和应激状态均可诱导其生成。在炎症等应激过程中ＩＬ－６可能为诱导者。在不降低疗效的情况下该蛋白可解除抗肿瘤药物ｃＤＤＰ的副作用，然而又与肿瘤对ｃＤＤＰ的抗药性密切有关。金属硫蛋白与炎性肠病、妊娠中毒症、肝脏疾患等多种疾病密切相关。

Metallothioneins are attractive substances, One of the features of these proteins is the inducibility in response to heavy metals, to a great variety of metabolites and to stress factors. In mammalia, their synthesis may be induced by interleukin- 6 in response to inflammation. Metallothionein could prevent renal toxicity of cDDP without compromising its anticancer activity.However, metallothionein is also implicated in the resistance to cDDP.There are now good evidences that metallothionein is involved in many diseases, such as inflammatory bowel disease, toxemia of pregnancy, liver disease, etc.