细胞因子对中枢神经系统海马脑区的作用

Effects of Cytokines on Hippocampus in Central Nervous System

细胞因子是一组多肽蛋白，一般认为其主要功能是介导非特异性免疫反应、促进未成熟白细胞增殖、分化和生长等。但近年来的研究表明，这些在免疫系统中起重要作用的调节因子及其受体也存在于中枢神经系统（ＣＮＳ）中，并发现它们对ＣＮＳ中某些神经元和胶质细胞的生理功能有调控作用。本文综述细胞因子白细胞介素１（ＩＬ－１）、白细胞介素２（ＩＬ－２）和白细胞介素６（ＩＬ－６）对ＣＮＳ海马脑区作用的研究进展。

Cytokines consist of a group of polypeptides,whose main functions are considered to be mediating the non-specific immune reaction and promoting differntiation, proliferation and growth of white blood cells. But according to recent studies, these cytokines such as interleukin-1(IL-1), interleukin-2(IL-2)and interleukin-6(IL-6)and their receptors are also found in the central nervous system(CNS)and may play a role in medulating the physiological functions of neuronal and glial cells in CNS. In this review, we summarize the representative studies concerning mainly the interleukins'effects on the hippocampus.