抑制素亚基基因在哺乳类动物卵巢的表达与调控的研究进展

Progress in the Study of Inhibin Subunit Gene Expression and Regulation in Mammalian Ovary

抑制素（ｉｎｈｉｂｉｎ）是由二硫键连接的α和β两个不同亚单位所构成的糖蛋白，它具有抑制卵泡刺激素（ＦＳＨ）的合成和分泌的作用。β亚单位借助二硫键尚可形成β亚单位二聚体──激活素（ａｃｔｉｖｉｎ），它则具有刺激ＦＳＨ分泌的作用。本文介绍了抑制素亚基ｃＤＮＡ的克隆及抑制素亚基基因在哺乳类卵巢表达与调控的研究进展，并指出在研究抑制素基因表达时应予注意的问题。

Inhibin is a glycoprotein hormone composed of an α-subunit and a β-subunit.It suppresses pituitary FSH secretion. Activin is a dimer of β-subunits of inhibin,which stimulates pituitary FSH secretion. This review is a survey of recent research progress in gene expression and regulation of inhibin/activin,particularly pointing out some questions in studying gene expression of inhibin.