细胞因子受体的组成、结构功能及信号传导机制

The Classes,Structures,Functions and Signaling Transduction of Cytokine Receptors

细胞因子受体种类繁多，分属于不同受体超家族。活化受体的功能可分为：ＰＴＫ型受体或其结合蛋白具有ＰＴＫ活性、丝／苏氨酸蛋白激酶型受体以及与Ｇ蛋白耦联的受体等。不同受体与其配体结合后，通过对受体后信号传导成分的可逆的磷酸化反应传递信号，最终通过对其终端成分，如酶活力、基因表达、细胞骨架蛋白的功能、膜通透性等的调节，导致细胞的生物效应。

There are many kinds of cytokine receptors that belong to different receptor families. Most cytokine receptors function as:(1) receptor tyrosine kinase and tyrosine-kinase-associated receptor;(2) receptor serine/threonine kinase;(3) G-protein linked receptor.Following binding with cytokines and activation,the receptors trigger different cascade of intracellular protein phosphorylation to transduct signals,thereby altering the cell's pattern of gene expression and leading to biological effects.