摘要
本实验用电生理和免疫组化方法观察了肾上腺髓质素（ａｄｒｅｎｏｍｅｄｕｌｌｉｎ，ＡＭ）对正常和高血压大鼠血压的影响和对主动脉环张力的作用以及ＡＭ在一些组织中的分布特点。结果显示ＡＭ对高血压大鼠的降压幅度远大于正常鼠；对主动脉环张力的降低作用具有剂量依赖性和内皮依赖性；ＡＭ免疫组化反应除在嗜铬细胞瘤和肾上腺髓质细胞内呈阳性反应外，在肺、肾和心肌组织内都显示出不同程度的阳性。提示ＡＭ在机体血压和循环调节中具有重要作用。
The effect of adrenomedullin (AM) on blood presure and tension of aortic rings were studied in normal and in either spontaneous or renal hypertensive rats(SHR/RHR). The distribution characteristics of AM in viscera was also investigated. It was found that the hypotensive action of AM was far more prominent in hypertensive than in normotensive rats. The tension lowering action on the aortic rings is dose dependent and requires the presence of endothelium. lmmunohistochemistry reactivity of AM of different degrees were also found in lung, kidney and myocardium, in addition to cells of pheochromocytoma and ndrenomedulla. It was suggested that AM may play an important role in the regulation of blood presure and visceral blood circulation.
出处
《生理学报》
CAS
CSCD
北大核心
1995年第4期408-411,共4页
Acta Physiologica Sinica
