炔诺酮对人早孕蜕膜和绒毛超微结构的影响

Effects of Norethisterone on Ultrastructure of Human Decidua and Trophoblast Cells

用炔诺酮（５ｍｇｑ８ｈ×５天）抗早孕后作人工流产，对蜕膜和绒毛的超微结构进行观察。结果显示绝大部分蜕膜和绒毛滋养细胞均发生不同程度的退变和坏死。蜕膜组织中大蜕膜细胞和绒毛合体滋养细胞变性坏死较重，而蜕膜颗粒细胞和细胞滋养细胞仅轻度变性。细胞退变的超微结构特征皆以线粒体肿胀和粗面内质网扩张为先导，继之，线粒体固缩伴高电子密度颗粒沉积，内质网不规则扩张，直至细胞全面崩解。本文就炔诺酮通过引起子宫局部缺血而导致蜕膜和绒毛滋养层细胞变性坏死的可能性进行了讨论。

With norethisterone(5 mg,q8hx5 days)against early pregnancy,the features of ultrastructure of the decidua and the trophoblast cells were observed.The specimens were directly obtained by induced abortion from the volunteers administered with norethisterone.Most of the decidua and villous trophoblast cells showed a varying degeneration and necrosis,first swelling of the mitochondria and rough endoplasmic reticulum,and further developing into the shrunken mitochondria with round,black-appearing matrix aggregates and the irregular dilatations of rough endoplasmic reticulum with ribosomes disappearing.These results suggest that the effect of the norethisterone on decidua and trophoblast cells is an extensive change of ischemic necrosis through possibly relative deficiencies of blood supply by the roles of progestin and testosterone of norethisterone.