含不同剂量消炎痛γ型IUD比较性研究

Comparative Study ofγ- IUDs with Different Doses of Indomethacin

本研究对三种含不同剂量消炎痛的ｒ－ＩＵＤ进行比较性研究，即含消炎痛２５±３ｍｇ，１８±２ｍｇ和不含消炎痛的γ－ＩＵＤ对照组各３００例，共９００例，于１９９２年１０月～１９９３年５月放置，放置后进行定期随访，随访率１００％，资料按生命表法统计一年时三组ＩＵＤ累计妊娠和脱落率均甚低。因症取出率以无药组最高为３．０５，一年时继续存放率γ２５ＩＵＤ组为９８．６６，γ１８ＩＵＤ组为９８．３３均明显高于γ０ＩＵＤ组的９４．３２／１００妇女，三组各测月经血量１５例，均与放置前比较，γ２５ＩＵＤ组放置后３～１２月月经量可减少３３．５～５．２％，γ１８ＩＵＤ组无明显改变，γ０ＩＵＤ组月经量有所增加。研究结果说明在三种ＩＵＤ中γ２５ＩＵＤ组含消炎痛量为较合理的配伍剂量。

The present study was conducted to compare the 3 kinds ofγ-IUDs containing different doses of Indomethacin,namely 25±3mg(γ25-IUD),18±2mg(γ18-IUD)and 0 mg(γ0 IUD).Altogether 900 cases were randomly divided into 3 groups(300 cases each).Insertions were made during the period from October,1992 to May,1993 with a 100% postinsertion periodical follow-up rate,and statistics were made according to the life table method.The 1 year cumulative pregnancy and expulsion rates were all very low in the 3 groups.The removal rate was highest in theγ0-IUD group(3.05).The 1 year continuation rates in theγ25-IUD group and theγ18-IUD group were 98.66 and 98. 33,respectively,which were significantly higher than 94.32/100 women in theγ0 -IUD group.15 cases in each group had their menstrual blood measured and compared with their preinsertion assessment.the 3￣12 months postinsertion blood loss in the γ25 - IUD group had been reduced by 33.5￣5.2%.There was no significant change in the r 18 -IUD group. But the menstrual blood was some increased in theγ0-IUD group. The results showed that the indomethacin content in theγ25-IUD would be a more rational and compatible dose.