两种杂交群（BALB／c♂×不同♀系）与BALB／c小鼠繁殖性能及单抗腹水产量的比较

Comparison of Generative Ability and Monoclonal Antibodies Producion in Ascites Between Two Hybrid Strains and BALB/c Mice

对两种杂交群（ＢＡＬＢ／ｃ♂×ＫＭ，ＢＡＬＢ／ｃ♂×ＬＡＣＡ♀）的繁殖能力及制备单抗腹水的产量同ＢＡＬＢ／ｃ近交系进行比较。实验表明，两杂交群的各项繁殖指标均优于ＢＡＬＢ／ｃ，总离乳鼠数分别为ＢＡＬＢ／ｃ的１．９８、２．０７倍，接种人肺炎支原体Ｆ８瘤细胞，ｋＣＦ１（ＢＡＬＢ／ｃ×ＫＭＦ１小鼠）的腹水产量为ＢＡＬＢ／ｃ的２．５倍，效价相同；制备六种单抗腹水ＬＣＦ１（ＢＡＬＢ／ｃ×ＬＡＣＡＦ１）的产量均优于ＢＡＬＢ／ｃ，分别为ＢＡＬＢ／ｃ的１．１７～２．８８倍，除Ｅ１０抗体滴度低外，其它各抗体效价相同或接近于ＢＡＬＢ／Ｃ。

The generative ability and monoclonal antibodies production in ascites be-tween two hybri strains(BALB/ c♂×KM♀, BALB/ c♂×LACA)and BALB/ cmice were compared。 The experiments show that all results of both bybrid strains in genera-tion are better than BALB / c。 The total weaners of two hvbrid strains are l.98 and 2.07 times as many as BALB / c。The ascites production of(BA LB / c × KM) KCF1 in antimycoplasma pneumoniae is 2.5 times the volume of BALB / c and both titers are equal。The ascites production off(BALB / c♂×LACA) LCF1 in 6 species antibodies are all higher than BALB / c。They are l.17──2.88 times as much as BALB / c individually,and the titers are equal or close to the titers of BALB / c except E10。