磷脂酰胆碱对大鼠术后腹腔粘连的影响

Influence of Phosphatidylcholine On Post-operative Peritoneal Adhesions In Rats

腹腔粘连是外科术后的一个常见并发症，也是腹膜透析失败的原因之一。本文观察了可溶性和不溶性磷脂酰胆碱对大鼠术后腹腔粘连的影响。结果发现生理盐水对照组（ｎ＝１５）平均粘连程度为２．５度，可溶性磷脂酰胆碱组（ｎ＝１５）腹腔粘连程度显著减轻，平均为１．３度，而不溶性磷脂酰胆碱组（ｎ＝１５）腹腔粘连程度加重，平均为３．４度，本文提示，可溶性磷脂酰胆碱腹腔应用可有效的防止术后腹腔粘连发生。

Peritoneal adhesion is a common complication of abdominal surgery。 It is alsoa major cause of peritoneal dialysis failure。We studied the effect of intraperitoneal solubleand insoluble phosphatidylcholine on postoperative peritoneal adhesions in rats。The meanadhesion score(MAS)in the saline group(n=15) was 2.5, which was significantly higherthan that of the soluble phosphatidycholine group (MAS=1.3,n=15),but significantly low-er than that of the insoluble phosphatidylcholine group(MAS=3.4,n=15)。This resuIt sug-gest that intraperitoneal soluble phosphatidylcholine may prevent postoperative peritonealadhesion effectively。