免疫酶法检测血清EB病毒─IgA／VCA对鼻咽癌诊断的价值

Valre of Detection of Serum Epstein─Barr Virus IgA/VCA by Immunoenzyme Technique in the Diagnosis of Nasopharyngeal Carcionma

应用免疫酶法对放疗前鼻咽癌病人９９０例、放疗后临床缓解鼻咽癌病人１１６８例、放疗后复发的鼻咽癌病人７６例、头颈部其它恶性肿瘤病人９６例、鼻咽部非癌疾病２１９２例和正常人２３２１名血清的ＥＢ病毒ＩｇＡ／ＶＣＡ抗体进行了检测，阳性率分别为９５．９５％、７７．３９％、９８．６８％、３２．２９％、１２．５４％和０．１７％。结果提示免疫酶法检测ＩｇＡ／ＶＣＡ抗体对鼻咽癌诊断及监测病情有重要的临床价值。

Serum Epstein─Barr virus(EBV)IgA/VCA were detected hy immunoenzyme techniquein 990 nasopharyngeal carcinoma(NPC)patients before radiation,1168 NPC patients after raditqtion withremission,76 NPC patients after radiation with recurrence, 96 patients with other maligiiancies of headand neck. 2192 patients with nonmalignant diseases of nasopharynx and 2321 normals. The positive rate ofserum EBV─IgA/VCA were 95.95%,77.39%, 98.68%,32.29%, 12.54%and 0.17%,respectively.The results suggest that the detection of serum EBV─IgA/VCA by immunoenzyme technique is of greatvalue in clinical diagnosis of NPC and monitoring deveopment of disease.