摘要
作者采用噻唑蓝（ＭＴＴ）法，对人体手术切除的原发性肝细胞癌的新鲜标本，作顺铂、卡铂、丝裂霉素、阿霉累和５氟脲嘧啶的抗癌敏感药物试验，试图预测出针对性较强的化疗药物，为临床科学合理地选择用药提供可靠依据。作者共检测４９例原发性肝细胞癌，结果显示，对两种药物敏感者１４例，占２８．６％，对其它药种敏感者很少，敏感药物顺序与临床治疗结果大致相符。此结果可作临床药物选择时参考，在实体瘤药敏试验中，ＭＴＴ法仍然可行。
Chemosensitivity of hepatocellular carcinoma
fresh samples from 49 patients to cisplatin,carboplatin,mitomycin C,adriamycin and 5─
fluorouracil was assayed with MTT test.The results showedthat 14 cases of
patients(28.6%)were sensitive to 2 drugs in all determined drugs,Few patients are sen-sitive to
other drugs.The order of sensitivity to drugs was approximately in accordance with clinical
cura-tive effect.The results may be for clinical reference in selecting drugs.MTT test is useful
for determiningwhich drugs are effective for the solid tumors.
出处
《实用癌症杂志》
1995年第1期14-15,共2页
The Practical Journal of Cancer
关键词
肝细胞癌
MTT法
化疗药物
药敏试验
Primary hepatocellular
carcinoma
MTT assay
Sensitivity test
Chemotherapeutic drugs
