原发性肝癌病人外周血T淋巴细胞亚群变化的检测意义

Significance of Detecting Changes of T-Lymphocyte Subsets in Peripheral Blood of Patients with Primary Hepatic Cancer

近年来，众多研究已表明肿瘤宿主免疫功能的改变，主要表现为细胞免疫功能下降和体液免疫功能升高（１）。为了探讨原发性肝癌（ＰＨＣ）患者免疫功能改变情况及其临床意义，作者应用ＯＫＴ系单克隆抗体，通过间接免疫荧光法对３２例晚期原发性肝癌病人包括未能手术者１０例，手术切除后未复发者１２例或复发及转移的１０例病人进行外周血Ｔ淋巴细胞亚群的检测观察，并与健康人做了比较分析。作者断定ＯＫＴ系细胞检测可作为判断ＰＨＣ病人治疗和预后免疫监视的一个有价值的指标。

In recent years,many research works have demonstrated that the changes of immune function oftumor hosts chiefly express in decrease of cellular immune function and increase of humoral immune function,Inorder to investigate the changes of immune function of patients with primary hapatic carcinoma( PHC)and evaluatetheir clinical significance, peripheral blood T-Lymphocyte subsets of 32 cases of PHC were detected by OKT seriesmonoclonal antiboldies and indirect immunofluorescence. The cases included 10 unresectable late stage PHC,12successful resected cases without recurrence and 10 resected cases with recurrence or metastasis.The results werecompared with those of control group,It is conclude that OKT series lymphocyte detection may be used as a valuablemarker in immunosurveillance for judging the curative effect and prognosis of primary hepatic carcinoma。