乳腺癌患者手术前后免疫状况的测定

DeterminationofImmuneStatusbeforeandafterOperation inPatientswithBreastCancer

对３０例乳腺癌病人分别于术前、术后两周检测了静脉末梢血自然杀伤细胞（Ｎａｔｕｒａｌｋｉｌｌｅｒ．ＮＫ）活性和Ｔ淋巴细胞亚群状况，其中２０例于术后６周重复检测。结果显示，乳腺癌病人术前ＮＫ、ＯＫＴ４、ＯＫＴ４／ＯＫＴ８活性均降低，并随病情的进展呈减低趋势，在晚期病人中ＯＫＴ８增高尤其明显。术后２周与术前比较无显著性差异。术后６周时ＮＫ、ＯＫＴ４、ＯＫＴ４／ＯＫＴ８均明显回升，而ＯＫＴ８显著降低。由此可见手术切除癌灶对病人的免疫恢复起积极作用。相关分析表明ＮＫ活性与ＯＫＴ４、ＯＫＴ４／ＯＫＴ８呈正相关关系，说明机体免疫系统具有协同抗癌能力。

LDH一release method has been u sed to measu re NK activityand APAAP method to investigate Tlymphocyte sbu bse ts in 3 0 cases of prim ary breast can cer two weeks before and after operation. 20 ofthem wereassayed again 6 weeks after operation,The results showed that NK activity, OKT4 ,and OKT4 /OKT8 in the breastcance r patients were greatly decreased be fore operation , and had a tendency Of decreasing with the progress of thedisease ,but OKT8 had an increasing tendency ,especially in the advanced cancer. All results were similar when assayed2weeks after operation. NK activity ,OKT4 ,OKT4 /OKT8 were significantly increased in 6 weeks after operation, bu tOKT8 was significantly decreased. It shows that the resection of the tumor would be b enificial to the recovery of theim munocompeten ce of the pa tients with breast ca n cer. The cor relative analyses demonstrate that there is a positivecorrection between NK activity and OKT4,OKT4/OKT8 ,and proved that the immune system of orgnism possesses asy n ergistic anticancer capability.