摘要
本文作者分别检测了106例消化道良性疾病患者及78例癌肿患者血清CA19-9和CA50的含量,分析了肝脏、胰腺、胃及结直肠4组良,恶性疾病患者血清含量的变化及其临床意义。结果106例良性疾病CA19-9和CA50的上限值分别为34u/ml和14u/ml(x±2S),其诊断的敏感性和特异性如下:CA19-9对原发性肝癌分别为75.0%和86.9%,对胰腺癌分别为91.7%和100%,对胃癌分别为55.6%和100%;CA50对原发性肝癌分别为55.0%和78.3%,对胰腺癌分别为91.7%和100%,对胃癌分别为55.6%和100%。CA19-9与CA50有高中度相关性,肝癌r=0.62、胰腺癌r=0.67、胃癌r=0;90,P值均<0.01。因此认为CA19-9和CA50对消化道良、恶性疾病的诊断、鉴别有较高的临床价值,并对消化道癌肿有否转移及胃癌根治术是否彻底、术后有否复发的判断均具有一定临床意义。
The contents of CA19-9 and CA50 in serum of106 paptients with benign alimentary
cannaldiseases and7 8 patents with malignant tumors have been detected , and the chan ges
of these contents in Patients with benignandmallgnant diseases of liver , pancreas ,stomach
,and colorectum have been analysed, of the l06 patients,theupper limits of CA19- 9 and CA50
are 34 u/ml and l4 u/ml ( x土2S) ,respeetively. The sensitivityand specificity in diagnosisare
listed as follows. For liver cancer,cancer of pancreas and stomach,the sensitivity and
specificityofCA19-9 are 75. 0%and 86.9%,91.7%and l00%,55.6%and l00%,respectively,and the
sensitivityand specificity of CA50 are55.0%and 78.3%, 91.7%and l00%, 55.6%and
l00%,respectively.There are also high and mediumcorrelation between CA19-9 and CA50 for
above- mentioned diseases , that is,r= 0. 62,0.67and 0. 90(P<0.01),respectively . The authors
suggest that CA19-9 and CA 50 are of Certain value for clinical diagnosis of benign
andmalignantalim entay cannal diseases.They are also useful for detecting whether or not the
tumors in alimentary cannalhave metastasized , or stomach cancer had been cured completely
without recrrence after operation.
出处
《实用癌症杂志》
1995年第2期91-92,共2页
The Practical Journal of Cancer