CA_（19－9）和CA_（50）对消化道肿瘤的诊断价值

DiagnosticValueofCA19-9andCA50inAlinentaryCannalTumors

本文作者分别检测了１０６例消化道良性疾病患者及７８例癌肿患者血清ＣＡ１９－９和ＣＡ５０的含量，分析了肝脏、胰腺、胃及结直肠４组良，恶性疾病患者血清含量的变化及其临床意义。结果１０６例良性疾病ＣＡ１９－９和ＣＡ５０的上限值分别为３４ｕ／ｍｌ和１４ｕ／ｍｌ（ｘ±２Ｓ），其诊断的敏感性和特异性如下：ＣＡ１９－９对原发性肝癌分别为７５．０％和８６．９％，对胰腺癌分别为９１．７％和１００％，对胃癌分别为５５．６％和１００％；ＣＡ５０对原发性肝癌分别为５５．０％和７８．３％，对胰腺癌分别为９１．７％和１００％，对胃癌分别为５５．６％和１００％。ＣＡ１９－９与ＣＡ５０有高中度相关性，肝癌ｒ＝０．６２、胰腺癌ｒ＝０．６７、胃癌ｒ＝０；９０，Ｐ值均＜０．０１。因此认为ＣＡ１９－９和ＣＡ５０对消化道良、恶性疾病的诊断、鉴别有较高的临床价值，并对消化道癌肿有否转移及胃癌根治术是否彻底、术后有否复发的判断均具有一定临床意义。

The contents of CA19-9 and CA50 in serum of106 paptients with benign alimentary cannaldiseases and7 8 patents with malignant tumors have been detected , and the chan ges of these contents in Patients with benignandmallgnant diseases of liver , pancreas ,stomach ,and colorectum have been analysed, of the l06 patients,theupper limits of CA19- 9 and CA50 are 34 u/ml and l4 u/ml ( x土2S) ,respeetively. The sensitivityand specificity in diagnosisare listed as follows. For liver cancer,cancer of pancreas and stomach,the sensitivity and specificityofCA19-9 are 75. 0%and 86.9%,91.7%and l00%,55.6%and l00%,respectively,and the sensitivityand specificity of CA50 are55.0%and 78.3%, 91.7%and l00%, 55.6%and l00%,respectively.There are also high and mediumcorrelation between CA19-9 and CA50 for above- mentioned diseases , that is,r= 0. 62,0.67and 0. 90(P<0.01),respectively . The authors suggest that CA19-9 and CA 50 are of Certain value for clinical diagnosis of benign andmalignantalim entay cannal diseases.They are also useful for detecting whether or not the tumors in alimentary cannalhave metastasized , or stomach cancer had been cured completely without recrrence after operation.