儿童白血病感染与血浆纤维结合蛋白的关系

Fibronectin and Infection in Children with Acute Leukemia

目的研究纤维结合蛋白和白血病发生感染的关系，其是体内重要的生物活性物质。方法采用Ｌａｕｒｅｌｌ’ｓ火箭免疫电泳法检测３５例急性白血病患儿血中纤维结合蛋白水平，重点观察各种感染时的变化。结果急性白血病患儿无发生感染时血中纤维结合蛋白含量与止常对照无差别，有感染发生者Ｆｎ即显著降低，感染越严重血中Ｆｎ下降就越显著。结论血浆Ｆｎ水平动态监测不仅对了解急性白血病病理生理机制有益，而且对临床监测病情有帮助，更重要的是为临床治疗特别是发生严重感染的治疗提供一条新思路。

Objective To study the relationship of the plasma fibronectin and infection in children with acuteleukemia.It was well known that fibronectin is an important biological factor in human beings.Methods Immunoelectrophoresis was used in this study.There are 20 normal children in control group,35 patients with acute leukemia in study group. It was paid more attention to observe that the changesof fibronectiu in the cases with infection during chemical treatment.Results The levels of plasma fibronectin in cases with infection(87.81 ±20.93μg/ml) was significantly decreased than that in cases without infection (241.57 ±79.71μg/ml) and normal controts (226.41±51.20μg/ml).It was also observed that more serious infection, more decrease of plasma fibronectin.Conclusions Observations of plasma fibronectin in patients with acute leukemia could help us to takethe sense of infection and could give us a suggestion that fibronectin may be useful to control infection.