脂质过氧化损伤与新生儿硬肿症肺出血

Lesion of lipid peroxidation and scleredema neonatorum with pneumorrhagia

研究目的探讨脂质过氧化损伤与新生儿硬肿症肺出血的关系。研究方法新生儿硬肿症患儿１３５例，男９８例，女３７例。Ⅱ°硬肿５３例，Ⅲ°硬肿８２例。死于肺出血者２７例。患儿静脉血、肺出血液及心血过氧化脂质（ＬＰＯ）测定采用ＴＢＡ荧光法。结果Ⅱ°、Ⅲ°硬肿症患儿静脉血ＬＰＯ含量分别为（３．７４±０．３２）ｎｍｏｌ／Ｌ和（５．１９±０．６５）ｎｍｏｌ／Ｌ（Ｐ＜０．０１），肺出血发生率分别为１１．３２％、２５．６％（Ｐ＜０．０１）。２７例肺出血患儿，肺出血液与心血ＬＰＯ含量分别为（８．０７±０．９５）ｎｍｏｌ／Ｌ、（５．６１±０．６６）ｎｍｏｌ／Ｌ（Ｐ＜０．０１）。结论新生儿硬肿症肺出血发生率随硬肿程度加重而增加，并与血清ＬＰＯ浓度呈明显正相关。肺内脂质过氧化损伤是造成新生儿硬肿症肺出血的重要原因。

Objectve To search for the relationship between the lession of lipid peroxidation and scleredema neonatorum with pneumorrhagia.Methods There were 135 patient with scleredema neonatorum,98 males and 37 females.Scleredema Ⅱ°53 cases and Ⅲ°82 cases.There were 27 camps of death with pneumorrhagia.The lipid peroxide(LPO)in venous blood,pneumorrhagia blood and endocardial blood was determined by TBA fluorescence method.Results The contents of LPO in venous blood of Ⅱ°and Ⅲ°scleredema were 3.74 ±0.32 nmol/L and 5. 19 ±0.65 nmol/L respectively(P<0.01),the rates of pneumorrhagia were 11.32% and 25.6% resnectively (p<0.01).The contents of LPO in pneumorrhagia and endooardial blood were 8.07±0.95 nmol/L and 5.61±0.66 nmol/L respectively(P<0.01) in the 27 child patients with pneumorrhagia.Conclusions With the level of scleredema worsened,the rate of pneumorrhagia of scleredema neonatorum was increased grandually,and it shows obviously positive correlation with LPO's content.Intrapulmonary lesion of lipid peroxidation is an important factor to result in pneumorrhagia of scleredema neonatorum.