老年脑梗塞患者外周血T细胞亚群的变化

Studies on changes of T lymphocyte subtypes in elderly cerebral infarction patients

本文运用单克隆抗体直接免疫荧光染色法测定３１例老年急性脑梗塞患者急性期外周血Ｔ细胞亚群ＯＫＴ系列，包括ＯＫＴ３、ＯＫＴ４、ＯＫＴ８及ＯＫＴ４／ＯＫＴ８比值，并与正常老年人进行了对照，结果发现老年急性脑梗塞患者ＯＫＴ３、ＯＫＴ４降低（Ｐ均＜０．００１），ＯＫＴ８增高（Ｐ＜０．０１），ＯＫＴ４／ＯＫＴ８比值降低（Ｐ＜０．００１），与正常老年人相比，有非常显著差异。表明老年急性脑梗塞患者存在明显的Ｔ细胞免疫功能的异常。

In this study, we utilized the OKT monoclonal anti-human T lymphocyte antibodies to determine the levels of OKT3, OKT4,OKT8, and OKT4/OKT8 in 31 patients over 60 years old suffered from acute cerebral infarction. The results showed that OKT3,OKT4 and OKT4/OKT8 were decreased (P<O. 01),and OKT8 was increased (P<O.01) in these patients as compared with the controls. It means that there is a disorder of T lymphocyte immune function in acute cerebral infarction patients over 60.