老年心血管疾病患者的高胰岛素血症

Hyperinsulinemia in aged patients with cardiovascular diseases

用放免法测定１０６例三种老年心血管疾病患者空腹血胰岛素含量，并与３２例健康老年人比较。结果显示，老年冠心病、高血压病、高脂血症患者其含量显著增高（Ｐ均＜０．０１），并分别与空腹血糖、甘油三酯含量呈现显著正相关（ｒ＝０．３４８３、０．２２１２；Ｐ＜０．００１、＜０．０５）。提示冠心病、高血压病尤其是高脂血症患者存在胰岛素抵抗导致的高胰岛素血症，并与机体的糖代谢、脂质代谢密切相关。因此，动态监测这些疾病患者胰岛素含量很有必要，并以此为依据制定或调整治疗方案，以改善胰岛素抵抗现象。

The baselin serum insulin concentrations in 106 aged patients with three kinds of cardiovascular diseases were measured by radioimmunoassay and compared with 32 healthy aged persons. The result showed that the concentrations were significantly higher in coronary heart disease, primary hypertension and hyperlipemia than in healthy aged persons (all P<O. 01) and they had significant positive correlations with either the fasting serum glucose or the serum triglyceride. This study suggests that in these diseases, especially in hyperlipemia, hyperinsulinemia is caused hy insulin resistance and is closely related to the carbohydrate and fat metabolism of the body. Therefore,dynamic monitor of baseline serum level is necessary in these diseases,in order to make or adjust the therapeutic plan to combat the insulin resistance.