国产与英国产布洛芬对类风湿关节炎双盲治疗的对比观察

BRUFEN PRODUCED IN CHINA VS ENGLAND IN THE DOUBLE-BLIND MANAGEMENT OF RHEUMATOID ARTHRITIS

对31例诊断明确的类风湿关节炎病人应用国产及英国产布洛芬1800mg/d,进行了随意抽样双盲试验,观察了在5周的治疗过程中及治疗后有关疾病的症状和体征的改善情况。两种药物对减轻关节的疼痛感、肿胀及晨僵显示了有统计学意义的相近的能力;而对20米步行时间及双手握力也显示了相近的无统计学意义的改善能力。国产布洛芬治疗组有4例发生轻微副作用:1例皮疹未经处理自行消失,3例上腹部不适加用对症药后缓解;英国产布洛芬治疗组有1例用药后5周因面部及周身浮肿、月经增多而被迫停药;另2例分别发生胃部不适及外耳肿痛,前者自行缓解,后者减药后症状消失。

A randomized double-blind trial compared brufen (600mgtid) produced in China with that made in England. A total of 31 cases ofdefinite rheumatoid arthritis were involved. Signs and symptoms of thediseases were observed during and after 5 weeks of treatment. Both durgs showed similar abilites to decrease the number of jointsafected by pain and swelling and to improve morning stiffness, withstatistical significance in both cases, No improverment in 20M meterwalking time or grip strength of both hands was seen. Four cases of mild side-effects were reported in China's brufen studygroup, but England's brufen had 1 case of anasarca and menorrheanecessitating discontinuation of treatment.