苯妥英钠剂量方案个体化方法的研究

A STUDY OF METHODS ABOUT DOSAGE REGIMENS INDIVIDUALIZATION FOR PHENYTOIN

在通常门诊治疗条件下,监测癫痫病人的血清苯妥英钠浓度,得到一对或一对以上每日剂量稳态水平数据共78例。用我们提出的二点法和PKPM法估计个体动力学参数,进而预测每日剂量,结果令人满意。我们认为,在门诊治疗条件下,把这两种方法结合使用,是更可取的。

A data set consisting of 78 patients, each have one pairor more of dosage-steady-state phenytoin level, was obtained by morni-toring their serum phenytoin concentration under routine ambulatory trea-tment. Two-point method and PKPME method were put forward toestimate individual phenytoin kinetic parameter and predict individualdosage. The predicting results were satisfactory. We think it is preferableto combine above two methods on the condition of ambulatory treatment.