摘要
分析了73例原发性肺癌患者治疗前后(手术切除16例,放疗28例,化疗29例)血清sIL-2R和TNF-α的变化。结果表明:(1)sIL-2R和TNF-α均显著高于正常对照组(P<0.01),肿瘤越晚期升高越明显(P<0.001);(2)治疗后sIL-2R和TNF-α都明显下降(P<0.01).但各治疗组下降程度不同,放、化疗组比手术切除组下降更显著;(3)sIL-2R和TNF-α在肺癌病人呈正相关(r=0.34),机理不明。结果提示,血清sIL-2R和TNF-α可作为肺癌患者免疫功能的监测指标之一,并可作为疗效判断的参考。
The serum levels of soluble interleukin-2 receptors(sIL-2R)and tumor necrosis factor-alpha(TNF-α)in 73 cases of patients with primary lung cancers were measured with double-antibody sandwich enzyme immunoassay(ELISA),and their clinical significance was analysed.The results:(1)there was a significant increase in serum sIL-2R and TNF-α levels in all patients with primary lung cancers compared with healthy subjects(P<0.01).especially in advanced cases;(2)serum levels of slL-2R and TNF-α declined markedly(P<0.01)after treatment, which varied with groups of different treatments.Moderate decline was seen in patients subjected to pulmonary resection(P<0.05) and remarkable decrease in patients after radiotherapy and chemotherapy(P<0.001);(3)there was a positive correlationship between sIL-2R and TNF-α in primary lung cancers(r=0.34),but the mechanism of their correlationship is not clear at present.The results have suggested that the serum level of sIL-2R and TNF-α detection might be a useful method of monitoring the immune function of primary lung cancer victims.
出处
《实用肿瘤杂志》
CAS
北大核心
1995年第4期207-209,共3页
Journal of Practical Oncology