肺癌患者血清sIL－2R和TNF－α的检测及其临床意义

Clinical significance of detecting serum sIL-2R and TNF-αlevels in patient primary lung cancer

分析了７３例原发性肺癌患者治疗前后（手术切除１６例，放疗２８例，化疗２９例）血清ｓＩＬ－２Ｒ和ＴＮＦ－α的变化。结果表明：（１）ｓＩＬ－２Ｒ和ＴＮＦ－α均显著高于正常对照组（Ｐ＜０．０１），肿瘤越晚期升高越明显（Ｐ＜０．００１）；（２）治疗后ｓＩＬ－２Ｒ和ＴＮＦ－α都明显下降（Ｐ＜０．０１）．但各治疗组下降程度不同，放、化疗组比手术切除组下降更显著；（３）ｓＩＬ－２Ｒ和ＴＮＦ－α在肺癌病人呈正相关（ｒ＝０．３４），机理不明。结果提示，血清ｓＩＬ－２Ｒ和ＴＮＦ－α可作为肺癌患者免疫功能的监测指标之一，并可作为疗效判断的参考。

The serum levels of soluble interleukin-2 receptors(sIL-2R)and tumor necrosis factor-alpha(TNF-α)in 73 cases of patients with primary lung cancers were measured with double-antibody sandwich enzyme immunoassay(ELISA),and their clinical significance was analysed.The results:(1)there was a significant increase in serum sIL-2R and TNF-α levels in all patients with primary lung cancers compared with healthy subjects(P<0.01).especially in advanced cases;(2)serum levels of slL-2R and TNF-α declined markedly(P<0.01)after treatment, which varied with groups of different treatments.Moderate decline was seen in patients subjected to pulmonary resection(P<0.05) and remarkable decrease in patients after radiotherapy and chemotherapy(P<0.001);(3)there was a positive correlationship between sIL-2R and TNF-α in primary lung cancers(r=0.34),but the mechanism of their correlationship is not clear at present.The results have suggested that the serum level of sIL-2R and TNF-α detection might be a useful method of monitoring the immune function of primary lung cancer victims.