摘要
观察实验组（腹腔注射米非司酮）和对照组（腹腔注射蒸馏水）小鼠动情周期的变化。结果表明：对照组注水前后小鼠动情周期无明显变化（４．９／５．１ｄ，Ｐ＞０．０５）；实验组小鼠给药后动情周期明显延长（５．３／１１．２ｄ，Ｐ＜０．０１）。给药后小鼠的动情间期、前期及动情期（１．５／１．７、１．３／１．４、１．３／１．５ｄ）变化不大，但动情后期明显延长（１．２／６．６ｄ）。据此推测ＲＵ４８６可能不影响排卵，但对排卵后黄体的形成、功能维持及退化有一定影响。
The antiprogesterone mifepristone(RU486)was utilized for evaluating the effects on mouse oestrous cycle.Each mouse was injected into abdominal cavity with 1 mL RU486(2.5 mg/mL)(as experimental group)or 1 mL distilled water(as control group)respectively at the diestrus.After injection,the average days of oestrous cycle in animals of the experimental group changed from 5.3 to 11.2 d, whereas varied from 4.9 to 5.1 d in the control group.The changes of the length of the diestrus, proestrus and estrus were not clear,but the elongation of the metestrus was significant.These results showed that RU486 might exert some influences on the formation and regression of the corpus luteum.
