摘要
对人工发酵培育冬虫夏草进行急性和亚慢性毒性研究。大、小鼠经口ＬＤ＿（５０）均大于１０ｇ／ｋｇ体重，亚慢性毒性研究（９０ｄ喂养试验）３个实验组动物生长发育正常，在试验第４５ｄ与第９０ｄ所作血液常规、血液生化、脏体比及病理学检查，３个实验组绝大多数检测项目与对照组未见显著性差异，极个别检测项目有显著性差异，但其差异无实际意义。研究表明人工发酵培育冬虫夏草毒理学是安全的。
Researches regarding the acute and sub-chronic toxicities
of artificially fermented Cordyceps sinensis(AFCS) were conducted in this study. LD_(50) of oral
AFCS in both rat and mice were over 10 g/kg BW. After 90 d feeding of wealing rats ,all dosed
animals grew and developed well and the average body weight of each dosed group was
slightly higher than that of controls. The routine blood test, serum biochemical measurements,
organ/body ratios and pathological examinations of major organs of rats were also determined
in this study. The results showed that there was no difference between these indexes of dosed
groups and that ofcontrols. The results demonstrate that AFSC is basically a toxicity-free and
safe substance for rats.
