摘要
通过对４５５例老年及２２０２例非老年上腹不适者进行胃镜检查，采用胃窦部活检组织的组织学检查、Ｇｉｅｍｓａ染色及（或）细菌学培养以确立ＨＰ感染，结果显示，老年组ＨＰ感染率（７７．１％）显著高于非老年组（６５．１％）及健康组（２９．０％），统计学上均有显著性差异（Ｐ＜０．０１）。老年组组织学胃炎和胃溃疡的ＨＰ感染率及慢性活动性胃炎、慢性萎缩性胃炎、胃溃疡、胃癌、慢性胃炎伴肠上皮化生和异型增生的构成比均高于非老年组。我们的结论是，ＨＰ感染与一些老年人胃十二指肠疾病有明显的相关性，并随年龄增长而增加。提示ＨＰ感染是造成老年人胃十二指肠疾病组织学损害的病因之一。
n order to assese the relationship between Helicobacter pylori (HP) infection
and gastroduodenal diseases in the elderly, we investigated 445 of the elderly and 2 202 of the
nonelderly with upper gastrointestinal symptoms,undergoing routine upper GI
endoscopy.Biopsy speciments from the gastric antrum were taken to detect HP by histology
(Giemsa staining) and (or) culture. It was shown that the prevalence of HP infection not only
increased from 65. 1% in non-elderly group to 77. 1% in elderly one,which the effect of age reach
statistical significance (P<0. 005), but was much higher than that of asymptomatic donor
group(29%;P<0. 01). And in the elderly,the frequency of HP infection in histologic gastritis and in
gastric ulcer and the prevalence of chronic active gastritis,chronic atrophic gastritis ,gastric
ulcer and gastric carcinoma and intestinal metaplasia and dysplasia in gastritis were all much
higher than that of the non-elderly group. We conclude that HP infection is responsible for some
of gastroduodenal diseases in elderly and increases in prevalence with advancing
age,suggesting a possible etiologic role for the bacterium in the histologic lesion.
