摘要
人工感染斯氏狸殖吸虫的家犬顿服吡喹酮80mg/kg和120mg/kg后24小时童虫活力与对照组相似,电镜下仅见吸盘轻度收缩,体表稍肿胀;200mg/kg顿服和80mg/kg及120mg/kg分3次服虫体变化相似,活力均较对照组减弱,电镜下见吸盘强烈收缩,表皮显著肿胀,肠内容物停滞;200mg/kg分3次服后大部分虫体丧失活力,挛缩为弓形,电镜下见体棘断裂,皮纹紊乱,皮泡形成,线粒体破坏;300mg/kg分3次服后全部童虫无活力,挛缩为哑铃形或向腹面卷曲,颜色灰白,电镜观察皮纹消失,皮泡溃破,糜烂剥落,基质中线粒体浓缩。对吡喹酮杀灭肺吸虫的可能机制及治疗幼虫寄生型肺吸虫病的合适剂量与疗程作了探讨。
The experimental studies on the effect of praziquantel on vitality and ultrastructure of Pagumogonimus skrjabini juveniles in dogs were carried out.24 hours after single dose of 80 mg/kg or 120 mg/kg praziquantel was given to dogs P. O,vitality of the parasites was similar to that ' of the control and the electron microscopical observations showed they had the slightly contracted suckers and the swollen tegument.The parasites from, groups of 80 mg/kg and 120 mg/kg which were given by three times had weaken movement, markedly contracted suckers and highly swollen tegument.The juveniles fromgroups of 200 mg/kg and 300 mg/kg given by three times were vigourless, became bow-shaped or dumbbell-like and had tegumental swelling,erosion,peeling and the contracted mitochondria in the tegument by electron microscopy. Finally, the possible mechanism of killing Paragonimus of praziquantel and the optimal dose and course of treatment were discussed.
出处
《中国人兽共患病杂志》
CSCD
北大核心
1989年第1期29-31,共3页
Chinese Journal of Zoonoses
关键词
吡喹酮
斯氏狸殖吸虫
童虫
Paragonimiasis, Chemotherapy, Praziquantel, Ultrastructure