期刊文献+

呲喹酮对犬体斯氏狸殖吸虫童虫作用的实验研究 被引量:1

Experimental Studies on the Effect of Praziquantel on Pagumogonimus Skrjabini Juveniles in Dogs
全文增补中
导出
摘要 人工感染斯氏狸殖吸虫的家犬顿服吡喹酮80mg/kg和120mg/kg后24小时童虫活力与对照组相似,电镜下仅见吸盘轻度收缩,体表稍肿胀;200mg/kg顿服和80mg/kg及120mg/kg分3次服虫体变化相似,活力均较对照组减弱,电镜下见吸盘强烈收缩,表皮显著肿胀,肠内容物停滞;200mg/kg分3次服后大部分虫体丧失活力,挛缩为弓形,电镜下见体棘断裂,皮纹紊乱,皮泡形成,线粒体破坏;300mg/kg分3次服后全部童虫无活力,挛缩为哑铃形或向腹面卷曲,颜色灰白,电镜观察皮纹消失,皮泡溃破,糜烂剥落,基质中线粒体浓缩。对吡喹酮杀灭肺吸虫的可能机制及治疗幼虫寄生型肺吸虫病的合适剂量与疗程作了探讨。 The experimental studies on the effect of praziquantel on vitality and ultrastructure of Pagumogonimus skrjabini juveniles in dogs were carried out.24 hours after single dose of 80 mg/kg or 120 mg/kg praziquantel was given to dogs P. O,vitality of the parasites was similar to that ' of the control and the electron microscopical observations showed they had the slightly contracted suckers and the swollen tegument.The parasites from, groups of 80 mg/kg and 120 mg/kg which were given by three times had weaken movement, markedly contracted suckers and highly swollen tegument.The juveniles fromgroups of 200 mg/kg and 300 mg/kg given by three times were vigourless, became bow-shaped or dumbbell-like and had tegumental swelling,erosion,peeling and the contracted mitochondria in the tegument by electron microscopy. Finally, the possible mechanism of killing Paragonimus of praziquantel and the optimal dose and course of treatment were discussed.
出处 《中国人兽共患病杂志》 CSCD 北大核心 1989年第1期29-31,共3页 Chinese Journal of Zoonoses
关键词 吡喹酮 斯氏狸殖吸虫 童虫 Paragonimiasis, Chemotherapy, Praziquantel, Ultrastructure
  • 引文网络
  • 相关文献

参考文献4

  • 1郑时春,张敏如.吡喹酮对体外培养的斯氏肺吸虫的作用[J]中国药理学与毒理学杂志,1988(01).
  • 2肖树华,戴志强,张荣泉,薛海筹,邵葆若.吡喹酮对日本血吸虫皮层损害的扫描电镜观察[J]药学学报,1982(07).
  • 3肖树华,邵葆若,郭惠芳,徐月琴,王翠英,焦佩英,哈淑华.用生物鉴定法观察抗血吸虫新药吡喹酮在家兔体内的吸收、分布和排泄[J]药学学报,1980(03).
  • 4杨元清,杨惠中,肖树华,邵葆若,汤雪明,朱建国,张蕙心.吡喹酮对日本血吸虫及动物宿主肝脏作用的组织学观察[J]中国医学科学院学报,1979(01).

同被引文献4

引证文献1

;
使用帮助 返回顶部