结核性与肿瘤性胸腔积液IFN—γ活性的比较研究

Study on interferon-r Activity in Pleural Effussions in Two Cases

用ｒ－干扰素（ＩＦＮ—ｒ）单克隆抗体经ＡＢＣ－ＥＬＩＳＡ法检测结核性与肿瘤性胸膜炎胸腔积液２６例ＩＦＮ－ｒ含量。结果显示：结核性显著高于肿瘤性（Ｐ＜０．０１）。

nterferon-r(IFN-r),a cytokine secreted by activated T cells and natural killer(NK) cells ,hasimmunomodulatory effects on several cell types. IFN-r is probably the major cytokine responsible for the activation of macrophages, which aer mediators of momspecific,cell-mediated host defence .We assay the levels of IFN-r in 14 patients with tuberculous pleural effussion and 12 patient with mabignant pleural effussion The esperimental results show that IFN-r is higher in tuberculouspleural effussion than that in carcinomtous pleural effussion .