猪脾细胞干扰素抗流行性出血热病毒的初步研究

Inhibitive Effect to EHFV on Cell Culture by Porcine Spleen Intehferon

根文首次报道猪脾细胞干扰素在细胞培养中对流行性出血热病毒具有抑制作用,使感染细胞内病毒抗原的表达减少,并对细胞无毒性反应。此外,猪脾细胞干扰素和病毒同时作用细胞,或先感染病毒2小时后,再加猪脾细胞干扰素对病毒的抑制作用要大于先用猪脾细胞干扰素处理6小时后再感染病毒。此结果为猪脾细胞干扰素可用于治疗流行性出血热提供了依据。

In this paper, we first reported that the porcine spleen interferon ( PSIFH) were effectiue of inhibition to EHFv on cell culture, in which reducing of the viral antigen expressed in infected cells, and no toxicitg to cell, otherwise the inhibitive effect of the viral antigen time adding pSIFN to treat after 2 hours of infecte dcell were stronger than treated cell with PSIFN before infected with EHFv, The result showed that it provided the knowledge of usage of pSIFN to treat EHF.