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蛋白质能量营养不良小鼠腹腔巨噬细胞膜结构及吞噬功能的研究

A Study on the Cytomembrane Structure and Phagocytosis of the Peritoneal Macrophages(M ) ofMice with PEM
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摘要 喂小鼠去蛋白饲料造成小鼠蛋白质能量营养不良(PEM),用扫描电镜(SEM)和体外鸡红细胞吞噬试验观察其腹腔巨噬细胞(M)膜表面结构及吞噬功能变化。结果,随喂去蛋白饲料时间延长,小鼠体重下降,血清蛋白含量降低,M膜表面绒毛样凸起基本消失,M 的吞噬功能亦下降;改喂含17%蛋白质的饲料后,其腹腔M 膜表面结构和吞噬功能均可逐步恢复正常.提示,蛋白质缺乏造成的PEM直接导致了M 膜结构损伤和吞噬功能下降,但如及时补充蛋白质,这种损伤是可逆的. n this study, protein--energy malnutrition(PEM) of mice was resulted in by feeding protein- free blood, then normal diet (containing 17% protein ) for these with PEM. We observedcytomembrane structure and phagocytosis of peritoneal M of the mice with PEM by means ofscanning electron microscopy(SEM) and phagocytosis-- test in vitro. The resultS showed: 1. The viili--like Protrusion on the surface of M membrane were reduced progressively up to nearly disappearalong with the weight reducing of mice with PEM. 2. The phagocytic precentage and index ofperitoneal M in mice with PEM were significantly lower than that in normal mice. 3. It could berecovered through protein supplementation in thee.
出处 《苏州医学院学报》 1995年第1期37-39,74,共4页 Acta Academiae Medicinae Suzhou
关键词 蛋白质 营养不良 吞噬功能 巨噬细胞膜结构 protein -- energy malnutrition (PEM) sytomembrane structure of peritoneal M phagocytosis electron microscopy(SEM) (P. 37)
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