摘要
用Ｙ迷宫箱，于训练前１小时腹腔注射Ｂｅｒ，１２．５ｍｇ／ｋｇ─１，能明显促进小鼠的记忆、学习功能。并且Ｂｅｒ对东茛菪碱、戊巴比妥所造成的记忆获得障碍有明显的改善作用，但对乙醇所造成的记忆再现障碍的改善作用不明显。结果提示：Ｂｅｒ的促记忆可能与其抑制脑内ＡｃｈＥ及易化脑干网状结构上行激活系统有关。
Berberine l2.5mg/kg intraperinglly given at lhour before exercising,the learn andmemory of Mice were evaluated by Y maze method.Berberine can improve mouse learn and memory a-bility as well as significantly rectifying the momerial disorder caused by Scopolamine or pentobarbital,but it can′t ameliorate the retrieval memory disorder caused by Alcohol.The results demonstrated thatthe function of Berberine ′s improving memory may have a relation to inhibiting AChE and facilitatingascending reticular activating system.
出处
《泰山医学院学报》
1995年第2期83-85,共3页
Journal of Taishan Medical College
