喉癌细胞核DNA含量及形态参数的图象分析

STUDY ON NUCLEAR DNA CONTENT AND MORPHOLOGICAL PAPAMETERS IN LARYNGEAL CANCINOMAS

应用图象分析技术测定４６例喉癌，１０例乳头状瘤的细胞核ＤＮＡ含量及形态参数，以５例正常喉粘膜上皮细胞和同批癌旁间质淋巴细胞为对照。结果ＤＮＡ含量喉癌（ＬＣ）组与对照组（Ｐ＜００１），ＬＣ组与喉乳头状瘤（ＬＰ）组（Ｐ＜０．０５），ＬＰ组与对照组（Ｐ＜０．０５）。根据２ＣＤＩ与５ＣＥＲ转换的ＤＮＡ恶性程度（ＤＮＡＭＧ）将喉癌分为两组，结果两组生存期及颈淋巴结转移皆有显著性差异（Ｐ＜０．０ｌ，Ｐ＜０．０５）。探讨了ＤＮＡＭＧ做为一综合指标在喉癌的早期诊断及判断预后中的意义。

The nuclear DNA content and morphological parameters were measured in 46 laryn-geal carcinoma(LC)and l0 laryngeal papilloma(LP)by image analysis technique. Results showed thatthe DNA contents between LC and normo一epitheltium(NE)(P<0.01 )Lc and LP,(p<0.05)were sig-nificanfly different.The DNA content and morphological parameters showed no significant relationshipwith clinical outcome of the patients(P<0.05).With the aid of the DNA malignancy grade(DNAMG)two groups of patients(grade 0一grade l一)could be discrened with a highly significant difference intheir survival times(P<0.01)and region lymph node metastases(P<0.05).