Lennox-Gastaut综合征临床观察

Clinical Study of Lennox Gastaut Syndrome

Lennox Gastaut综合征(LGS)是一种儿童期顽固性癫痫。通过50例LGS患儿的长期随访观察,发现LGS病因是多样的。临床特点是紧张性发作、假性失神、肌阵挛、失张力性发作等。典型EEG是低于3/s慢尖慢波。本病治疗困难,未发现任何特效疗法,预后极差。提出对LGS的诊断意见,并推测其病生理的可能变化机制。

Lennox-Gastaut Syndrome (LGS) is a type of intractable epilepsy that occurs in childhood. In this study,50 patients with LGS were followed up from 1-10 years. LGS is a polyetiology. The most common seizure types are tonic seizure, atypical absense, myoclonic seizure and atonic seizure. EEG is characterized by slow spike-waves of less than 3/s. LGS is not responsible for the antiepileptic drugs. So far no drugs have been found to cure for LGS satisfactorily in a long time. The prognosis of LGS is very poor. Almost all the children with LGS have retarded development. The suggestions about the diagnosis of LGS and its possible pathogenesis were discussed.