摘要
对扩张型心肌病(DCM)红细胞C_3b受体花环率(RCR)和红细胞免疫复合物花环率(RICR)、T淋巴细胞亚群(CD_3、CD_4及CD_8)和自然杀伤细咆(NK)活性进行了检测,并与其它性质的心脏病和正常对照组(NC)比较。结果表明:DCM患者RCR和NK活性均低于NC组(P<0.01,P<0.001),CD_8明显低于肥厚型心肌病(HCM)、慢性心衰患者(HF)及NC组(均P<0.01),而CD_4/CD_8高于其它三组(均P<0.01)还发现RCR与CD_8呈正相关(r=0.473,P<0.05),以上结果表明DCM患者红细胞和白细胞免疫均有异常,且二者相互影响,可能在DCM的发病中有意义。
Idiopathic dilated cardiomyopathy (DCM) is a disease in which immune aberration has been postulated but not confirmed. The frequency of peripheral blood T-lymphocyte subsets (CD3, CD4, and CD8) was evaluated in 30 patients with DCM and 20 normal control (NO subjects. In the meanwhile,the natural killer cells (NK)activity,the rosette formation rate of red cell C3b receptor and the rosette formation rate of red cell immune complex were also studied in 20 patients and 24 NC subjects. It showed: (1)the percentage of CD8 cells and the rosette formation rate of red ceil C3b receptor were significantly lower in DCM than in NC(P<0. 01,in all). (2)the NK cytotoxicity was statistically lower in DCM than in NC(P<0. 001). The results suggested that the cellular irn-munological disorders may be an important part of pathogenesis of DCM-
出处
《天津医药》
CAS
1995年第1期7-9,共3页
Tianjin Medical Journal
基金
山东省科委自然科学基金
