肺癌患者血中sIL-2R、TNF等含量变化的意义

Clinical Significance of slL-2R,β_2-mG and CEA Determination for the Diagnosis of Lung Cancer

肺癌患者常伴免疫功能的异常。sIL-2R、β_2-mG和TNF均为免疫反应介质,本文检测结果表明,肺癌患者sIL-2R、β_2-mG、TNF、CEA均明显升高,有远处转移者比无远处转移者升高更明显。腺癌患者血中CEA明显升高,肺小细胞癌血中TNF明显升高。sIL-2R、β_2-mG在三型肺癌间无明显差异。结果提示,肺癌患者细胞免疫功能低下,以上指标的测定有助于判断病情和预后。

Lung cancer is usually accompanied with changes of immunological function. Both Soluble in-terleukin-2 receptor (sIL-2R)and β2-Microglobin (β2-mG) are immunological reactors induced by tumor cells.The results showed t ha t sIL-2R,β2-mG and CEA were much higher in lung cancer pa-tients than those in normal controls. Mean serum levels of sIL-2R and β2-mG were significantly higher in metastatic patients than those in without malestases. Tumor necrosis factor (TNF)con-centration increased significantly in patients with small cell lung cancer. There were no significant intermarker correlations among these indices in cancer paiients. sIL-2R might be a new useful index for the diagnosis of the extent of the discase and have a hearing on treatment and prognosis.