用MR观察研究正常人大脑深部灰质核团铁沉积

Normal Deposition of Brain iron:Study Using MR Imaging

对257例年龄2～84岁非颅脑疾患病人的脑MRI进行回顾性研究,判定脑内铁沉积的MR表现。用SE序列对T_2WI信号强度进行分级观察,包括苍白球、黑质、红核、被壳、齿状核。结果表明:10岁以内T_2WI看不到低信号,25岁以上正常人大多数可见低信号。随着年龄增长,铁沉积逐渐增多,尤以苍白球为甚。70岁以上者铁更易沉积于被壳。总之,用MRI检查正常脑铁沉积,有助于铁沉积疾病的诊断。

Magnetic resonance (MR) images of the brain in 257 patients who had not known skull disease were retrospectively studied to determine the appearances of brain iron accumulation. The globus pallidus, red nucleus, substantia nigra, putamen and dentate nucleus were evaluated with T2WI spin-echo sequences and graded. The results suggested that decreased signal intensity could not be seen in these regions in patients less than 10 years old.In most patients it was seen by age 25 years. As patients grew up,the accumulation of brain iron increased,especially in globus pallidus. The brain iron could be more easily deposited in the putamen of patients over 70 years old. In general,the normal iron deposition as detected with MRI is helpful for diagnosing known iron-deposition diseases.