学龄儿童缺铁性贫血、隐性缺铁时血清苯丙氨酸、酪氨酸及维生素A、E含量的变化规律观察

The Observation on Changes of Serum Phenylalanine.Tyrosine, Vitamins A and E Levels in School-age Children with Symptomatic or Occult Iron Deficiency

观察42例学龄儿童各期铁缺乏症血清苯丙氨酸、酪氨酸及维生素A、E浓度在治疗前后的变化,并与20名健康儿童相比较。结果显示:缺铁儿童血清苯丙氨酸含量增高,酪氨酸降低,维生素A、E水平亦减低。口服硫酸亚铁治疗1个月后,随着铁实验指标的恢复正常,血清笨丙氨酸浓度下降,酪氯酸,维生素A、E上升,均达到正常范围。对此种变化的发病机理及临床意义略加讨论。提出:属含铁酶类的苯丙氨酸羟化酶在缺铁状态下活性降低,导致苯丙氨酸升高,而缺铁儿童存在的智能和行为障碍是否由苯丙氨酸代谢障碍(苯丙氨酸升高)引发,值得今后深入探讨。

The concentrations of serum phenylalanine ,tyrosine(Tyr) .vitamine A and vitamine E were examined be-fore and after the treatment in 42 school-age children with iron deficiency and in 20 normal children. The re-sults were as follows-serum content of phenylalanine in iron deficiency children had been elevated and Tyr,as well as Vit A and Vit E had been reduced. After these children were treated with oral ferrous sulfate for one month.along with gradually normalized level of serum iron,serum phenylalanine reduced. Tyr,Vit A and E increased until norma! ranges. The pathogeny and clinical significance of these changes were discussed briefly and considered that the higher level of phenylalanine was resulted from lower activites of phenylalaninase as a ferrochelatase in the conditior. of iron deficiency. However .whether the intellectual and behavior disturbance? in iron deficiency children were caused by dysbolism of phenylalanine (elevated level of phenylalanine )or not i.?worthy of further studies.