摘要
给ＳＤ大鼠预先鞘内注射阿片肽Ｋ受体拮抗剂Ｎｏｒ－ＢＮＩ，拮抗不同剂量ＤｙｎＡ＿（１－１３）鞘内注射所致瘫痪的大鼠实验结果表明，Ｎｏｒ－ＢＮＩ能对抗低剂量，而不能对抗高剂量ＤｙｎＡ＿（１－１３）所致瘫痪。研究提示：强啡肽Ａ在脊髓继发性损伤中的作用除经由阿片肽Ｋ受体解导外，还可能存在非阿片样解导途径。
AbstractThe role of Nor BNI,an antagonist ofopium peptide K,on
antagonizing the palsyinduced by DynA(1-13) in SD rats was studied. The rats were pretreated
with Nor BNI,thenwere given different dosages of DynA(1-13),bysubarachnoid injection.The
results showedthat Nor BNI was able to antagonize thepalsy induced by lower dosage of
DynA(1-13)rather than higher dosage. The study suggeststhat the role of DvnA(1-13) in the
secoi1darvinjury might be mediated not ony by opiumpeptide K receptor but also by Non
opioidmechanism. KEY WORD5:Nor BNI DynA palsy
出处
《铁道医学》
1995年第5期263-264,共2页
Railway Medical Journal
基金
国家自然科学基金
