棉酚铂（Ⅱ）配位化合物的合成及抗肿瘤活性研究

Platinum (Ⅱ) Complexes of Gossypol: Synthesis and Their Antitumor Activity

合成了二种顺式棉酚铂（Ⅱ）配位化合物ＰｔＡ_２（Ｇｏｓ）_（１／２）［Ａ_２＝（ＮＨ_３）_２或乙二胺（ｅｎ），Ｇｏｓ＝棉酚（Ｇｏｓｓｙｐｏｌ）］。元素分析、红外光谱分析和电导滴定提示这类新型化合物结构式为［Ａ_２Ｐｔ（Ｃ_（３Ｏ）Ｈ_（２６）Ｏ_８ＰｔＡ_２］。这二种化合物具有抗肿瘤活性，对小鼠ＥＡＣ的抑制率分别为５１．４３％、５７．１４％。

Cis-platinum (Ⅱ) complexes of gossypol, PtA_2(Gos)_(1/2),have been synthesized (A_2=(NH_3)_2 or ethylenediamine,Gos=Gossypol). Elemental analysis, IR analysis and conductometric titration indicated that the structures of these new compounds are [A_2 Pt(C_(30)H_(26)O_8)Pt A_2]. These compounds have antitumor activity and their inhibition ratio of EAC in mice are 51. 43%and 57. 14%respectively.