原位同种心脏移植术后早期急性排斥反应的监测与治疗

Monitoring and Treatment of Early Acute Rejection after Orthotopic Heart Transplantation

我院心外科于１９９４年３月成功地为１例１３岁晚期扩张型心肌病女性患者施行了原位同种心脏移植术。术后存活２８ｄ．因第三次心肌急性排斥反应抢救无效死亡。作者强调应采用多种抗排斥反应药物，且需小剂量，对使用抗胸腺细胞球蛋白药物应谨慎．尽管拥有众多的非侵入性检查，但没有一种非侵入检查技术能直接有效地诊断心肌排斥反应，心内膜心肌活检是监测心肌排斥反应最直接可靠的手段而不能被取代。

In March 1994,we successfully performed an orthotopic heart transplantation on a 13 years old girl with late stage dilated cardiomyopathy.The patient had lived 28 days and died of the third acute rejection after operation.The authors believe that multiple anti-rejection drugs should be used with a little dose and ATG should be introduced carefully.In spite of many noninvasive tests,none of techniques but transplanted endocardial biopsy can provide.direct assessment of rejection.