胎儿宫内发育迟缓模型孕鼠血浆TXA_2／PGI_2的比值及青心酮、山莨菪碱的效

Ratio of TXA_2 to PGI_2 in Pregnant Rats of IUGR Model and Effects of DHAP and Anisodamine

健康Ｓｐｒａｇｕｅ－Ｄａｗｌｅｙ种妊娠大鼠１０２只，均于妊娠第４天～第２０天仿Ｙｏｕｎｏｓｚａｉ法制备胎儿宫内发育迟缓模型．随机分成对照组、模型组、氨基酸组、青心酮组和山莨菪碱组，各组按规定给药，观察有关指标．结果表明：模型组胎仔发育明显迟缓，血红蛋白和红细胞压积水平升高，血栓素Ｂ_２／６－酮基－ＰＧＦ_（１α）（ＴＸＢ_２／６－ｋｅｔｏ－ＰＧＦ_（１α））比值明显高于对照组．以上指标在青心酮组和山莨菪碱组得到明显改善，收到一定疗效．

Animal model for intrauterine growth retardation(IUGR)has been produced in 102 pregnant Sprague-Dawley rats by passive smoking. The rats were divided into five groups: control group, model group, amino acids groups, DHAP group and anisodamine group.Blood samples were collected to examine Hb,φrbc,TXB2 and 6-keto-PGF1αThe results showed that, in model group the fetal growth significantly retarded, Hb,φrbc and TXB2/6-keto-PGF1αratio increased. In DHAP and anisodamine groups, some therapeutic effects have been observed and such abnormal changes could be corrected.