肝内IgG、IgM在乙型肝炎免疫病理中的意义

The Significance of Intrahepatic IgG, IgM in the Pathogenesis of Hepatitis B

运用免疫组织化学方法分别检测了５４例乙型肝炎（乙肝）患者、１３例非肝病者肝组织内ＩｇＧ、ＩｇＭ、ＨＢｓＡｇ，ＨＢｃＡｇ．结果：乙肝患者肝内ＩｇＧ、ＩｇＭ、ＩｇＧ／ＩｇＭ的检出率分别为７０．３７％、７０．３７％、９０．７４％，显著高于非肝病者的１５．３８％、７．６９％、２３．０８％；有活动性病变的不同类型肝炎患者之间其检出率差异无显著性意义；肝内ＩｇＧ、ＩｇＭ的分布与肝细胞损伤明显相关，与肝内ＨＢｓＡｇ、ＨＢｃＡｇ的表达部分相关．推测肝内沉积的ＩｇＧ、ＩｇＭ在乙肝免疫病理中有着重要作用，其本质可能是针对导致肝损伤的靶抗原的抗体．

Intrahepatic IgG , IgM,HBsAg, HBcAg were detected in the 54 cases of hepatitis B,13 cases of non-hepatitis by means of immunohistochemical method. The positive rate of IgG, IgM,IgG or IgM is 70.37%, 70.37%and 90.74%in the cases with hepatitis B,much higher than those of non-hepatitis subjects(15.38%,7. 69%, 23.08%). There was no significant difference among the various forms of hepatitis B. The distribution of IgG,IgM were associated with the injury of hepatic cells, partly associated with HBsAg, HBcAg expressed in the liver. It was inferred that intrahepatic IgG, IgM play important roles in the pathogenesis of hepatitis B, as the antibody defining the target antigens expressed on the cells.