摘要
研究了SL-益生素(SL-P)对小白鼠体重和单核吞噬细胞功能的影响。经急性毒性实验检查,该益生素无急性毒性,无急性致病作用。灌服SL-P10d后,小鼠体重较对照组有明显提高。经过SL-P处理后,小鼠腹腔巨噬细胞(PMφ)的吞噬率和吞噬指数较对照组有显著提高。灌服SL-P10d后,小鼠单核吞噬细胞的水解酶类:血清溶菌酶(血清LSZ),腹腔巨噬细胞溶菌酶(PMφLSZ),腹腔巨噬细胞酸性磷酸酶(PMφACP)的活性均有不同程度的提高,并呈现一定的剂量依赖关系,表明SL-P对小鼠单核吞噬细胞的吞噬和杀菌功能有明显的促进作用。
Effects of SL-probiotic preparation on the body weight and the phago-cytic functions in white mice were studied. Bioassay of its toxicity showed SL-P was non-toxic. Body weight of the treated mice increased significantly as compared with that of controls 10 days after treatment with SL-probiotic preparation. Phago-cytic activity, acid phosphatase activity, lysozyme activity of the peritoneal macro-phages of the tested mice were enhanced significantly as compared with those of normal controls. The same results were obtained with respect to serum lysozyme activity. These observations showed that SL-probiotic preparation could activate ma-crophage function in mice and hence enhancement of non-specific immunity.
出处
《微生物学报》
CAS
CSCD
北大核心
1995年第6期455-459,共5页
Acta Microbiologica Sinica
基金
国家"八五"科技攻关项目
