不同月龄婴儿接种DTP后血清中百日咳抗体水平的观测

The Serologic Response for Pertussis of Infants Administing DTP Vaccine at First Two Months and Three Months of Age

本文对比观察了２１３例２月龄、３月龄婴儿接种ＤＴＰ后百日咳抗体水平的变化，探讨了母传抗体对免后抗体增长的影响。结果表明２月龄、３月龄婴儿ＤＴＰ免疫后１个月和３个月血清中百日咳抗体达保护水平的百分率无显著性差异（ｘ￣２＝０．０３６，ｐ＞０．９；ｘ￣２＝０．３２７，ｐ＞０．５），免后１个月抗体ＧＭＴ无显著性差异（ｔ＝０．１７，ｐ＞０．５），免后３个月抗体ＧＭＴ３月龄组高于２月龄组（ｔ＝２．２２，ｐ＜０．０５）。我们还发现免前抗体水平与免后１个月ＧＭＴ虽有负相关（ｒ＝—０，７５４）的倾向，但总体上对抑制免后抗体应答不明显，因而建议将儿童ＤＴＰ基础免疫的起始月龄提前至２月龄进行。

Agglutinin levels against pertussis were determined in 213 infants who administed DTP vaccine for the pimary immunization serious at first two months and three months of age. 1 month after last primary immunization serologic evidence of pretective titers against pertussis and geometri mean titer(GMT)were similar in two study groups, respectively, 95. 83%, 95. 28% and 1 : 901.79, 1 : 943. 86. 3 months after last primary. immunization,agglutinin levels against pertussis were similar,respectively 70. 83%and 76. 10%. But GMT of three month regimen was higher than that of two month regimen ,respectively,1: 470. 38and 1 : 340. 82.We alse had found lower levels of transplacentally acquired antibody prior to immunization did not impair serologic response to pertussis antigan. However, We suggested infants administer DTP vaccine for the primary immunization at first two months of age.