献血员血清抗──HCV和HCV　RNA检测

Detection of Anti-HCV and HCV RNA in Serum of Blood Donors

本文对宜昌市的２９９９名献血员，５９４名自然人群的血清进行了抗－ＨＣＶ、ＨＣＶＲＮＡ检测，结果表明，献血员中抗－ＨＣＶ阳性２３例，阳性率为０．７７％。其中宜昌、巴东分别为０．７３％和０．７６％，沙市为０．８３％。地区、性别、城乡之间抗－ＨＣＶ阳性率无显著性差异（ｐ＞０．０５）。参照以往文献报导，此阳性率比国内报导的低，与国际的相一致。５９４名自然人群抗－ＨＣＶ结果均为阴性，献血员与自然人群之间抗－ＨＣＶ阳性率差异显著（ｐ＜０．０５）。２０例抗－ＨＣＶ阳性者中检出ＨＣＶ ＲＮＡ阳性６例，占３０％（６／２０），占受检献血员的０．２０％（６／２９９９），比武汉（０．８０％）低４倍，地区之间无显著差异（ｐ＞０．０５）。由此初步确认：宜昌市献血员中丙型病毒性肝炎感染低于国内某些大中城市、宜昌市（含七县二市）巴东县、沙市市是丙型病毒性肝炎低感染区。但存在无症状病毒血症携带者传染源。

Ant-HCV and HCV RNA in 2999 professional blood donors and 594 common people in Yichang city were dettermined. The results showed that the positive rate of anti-HCV was 0.77% (23/2999). They were 0. 73%, 0. 76% and 0. 83% respectively in Yichang, Badong and Shashi Was. There waw not different in area,sex and city or county (p＞ 0.05). According to documment, this positive rate was lower than that of the national ,showing no difference form that of international reports. The detection results of anti-HCV in 594 common people showed that all of subjects were negative ,having significat difference from the professional blood dorors (p＜0. 05). 6 cases of positive of HCV RNA were found in 20 cases of positive anti of HCV(30%),or 0. 2% in total blood donors (6/2999). It was the four times lower than that of Wuhan (0. 8%). But it did’nt show significant difference in regions (p＞0. 05). So the results confirmed tentatively that the infection rate of HCV in Yichang city was lower than that of other cities in China. Yichang (consist of 7 counties and 2 cities) ,Shashi city,Badong county are low-infection area of HCV.However there some no-symptom virusemia infections pathogen.