摘要
用高效液相色谱－电化学器方法，研究了丹皮酚对大鼠脑内单胺神经递质代谢的影响。结果表明，丹皮酚能增加大鼠纹状体及边缘区内多巴胺代谢物高香草酸（ＨＶＡ）和三羟苯乙酸（ＤＯＰＡＣ）含量，也能增加５－羟色胺代谢物５－羟吲哚醋酸（５－ＨＩＡＡ）的含量，对单胺递质ＮＡ及ＤＡ含量无明显影响。
This paper reported the effect of paeonol on monoamine metabolism in rat brain.This experiment was carried out with HPIC-electrochemical detector,The results showed that the levels of homovanillic acid(HVA) and dihydroxphenylacetic acid (DOPAC) in striatum and limbic areas increased after 40 minutes ip of paeonol 100mg/kg in rat.Increase in 5-hydroxyindoleacetic acid(5-HIAA)levels of in the striatum and limbic areas was also abserved.But the levels of monoamine transmitters nora-trenaline (NA) and DA remained unchange.
出处
《潍坊医学院学报》
1995年第1期20-22,共3页
Acta Academiae Medicinae Weifang
关键词
丹皮酚
单胺递质
二羟苯乙醇
高效液相色谱
paeonol
monoamine transmitter
dihydroxyphenylacetic acid
homovanillic acid
high performance liquid chromatography
